Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children

• Status: Not yet recruiting
• Trial end date: 2022-08-20
• Target enrollment: 0
• Participant gender: All

Summary

1. Comparison of the efficacy of Rituximab and ketogenic diet in controlling refractory seizures versus the traditional lines as corticosteroid and trace elements.

2. Improving the management of children with refractory seizures

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Rituximab; Trace Elements

Criteria

Inclusion Criteria:

• 1-Age 1 month up to 17 years 2-Both male and female 3-Epileptic patient on two tolerated and appropriately chosen and used antiepilptic drugs with no response

Exclusion Criteria:

• 1-Neonate 2-Epieptic patient on monotherapy 3-Conditions mimic epilepsy 4-Pseudo refractioness 5-Absolute contraindications for the use of diet therapy include carnitine deficiency (primary), carnitine palmitoyltransferase (CPT) I OR II deficiency, carnitine translocase deficiency, β-oxidation defects, pyruvate carboxylase deficiency, and porphyria 6-Contraindication for Rituximab:

1. Hypersensitivity to any component, murine proteins. b. Heart failure c. Active infection