Comparative Study of Rifaximin Versus Norfloxacin in the Secondary Prophylaxis of Spontaneous Bacterial Peritonitis

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to compare the effectiveness of rifaximin versus norfloxacin for secondary prevention of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sherief Abd-Elsalam
• Collaborator: Tanta University
• Treatments: Norfloxacin; Rifamycins; Rifaximin

Criteria

Inclusion Criteria:

• Previous episode of SBP

• Total protein in the ascitic fluid below or equal to 1.5 g/dL

Exclusion Criteria:

• Allergy to quinolones

• Antibiotic therapy in the 2 weeks preceding inclusion

• Recent ( within the previous 2 weeks) episode of digestive hemorrhage

• Hepatocellular carcinoma or other neoplasias able to shorten life expectancy

• Pregnant and lactating women