Comparative Study of Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Morbidly Obese Patients

• Status: Unknown status
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative residual curarization in the post anaesthesia unit has been associated to complications involving respiratory function and impaired laryngeal and pharyngeal muscles' function. Speed of reversal of neuromuscular blockade after administration of sugammadex versus neostigmine has been studied, but up to date no data are available concerning continuous acceleromyography monitoring of adductor pollicis and corrugator supercilii in morbidly obese patients undergoing weight loss surgery. The investigators' aim in this prospective, double-blinded study was to compare train of four ( TOF ) values, the presence or absence of clinical criteria of postoperative residual curarization , the dose requirements and the side effects of sugammadex and neostigmine for the reversal of rocuronium induced neuromuscular blockade in patients undergoing laparoscopic or open surgery for morbid obesity.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Patras
• Treatments: Neostigmine

Criteria

Inclusion Criteria:

• Body mass index (BMI) >40kg

• Age < 60

• Patients written consent to participate in the study

Exclusion Criteria:

• Cardiovascular disease (NYHA>2)

• Patients refusal to participate in the study

• Contraindication to epidural catheter placement (e.g anticoagulation, anti- platelets medication)

• coexisting neuromuscular disease

• history of allergic reaction to neuromuscular blocking agents

• history of difficult intubation

• creatinine levels > 159lmol/l