Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma

• Status: Completed
• Trial end date: 2020-02-15
• Target enrollment: 0
• Participant gender: Female

Summary

Study's objectives are to determine proportion of melasma cases in hyperthyroid patients and to compare severity of melasma before and after medications of three months hyperthyroid therapy using modified melasma area and severity index (mMASI) score. A quasi experimental (pre-post intervention) study was conducted in Jakarta in August 2019-February 2020.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dr.dr.Irma Bernadette, SpKK (K)
• Treatments: Methimazole

Criteria

Inclusion Criteria:

• Female with age range of 18 to 60 years old

• Newly diagnosed with hyperthyroid on a laboratory basis

• Diagnosed with melasma by dermatologist

Exclusion Criteria:

• Pregnant or breastfeeding

• Using hormonal contraception or history of using hormonal contraception within 1 year

• On anti-seizure therapy or hormone replacement therapy

• History of drug use that can affect the thyroid

• History of using topical hydroquinone in the last 3 months and / or using a topical steroid and / or an vitamin A analog and / or received chemical peeling in the last 1 month

• History of laser therapy and / or mechanical abrasion therapy in the past 9 months