Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility

• Status: Active, not recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: Female

Summary

The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A" gonadotropins alone, "B" short GnRH agonist, "C" multiple-dose GnRH antagonist, "D" long GnRH agonist and "E" combined protocol of GnRH antagonist and agonist) and the outcomes of ICSI. This comparative study will help clinicians to select the relevant protocol of ovarian stimulation related to the female infertility disorders.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lebanese University
• Treatments: Cetrorelix; Chorionic Gonadotropin; Ganirelix; Menotropins; Prolactin Release-Inhibiting Factors; Triptorelin Pamoate

Criteria

Inclusion Criteria:

• must not show any of the excluded criteria

• Patients affected by female infertility due to particularly Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome, Tubal Origin, Ectopic Pregnancy, Salpingitis, Tubal Block/Occlusion, Hydrosalpinx, Cervical/Vaginal, Endocrine, Endometriosis, Fibroids, Congenital Uterine Anomaly, Infections Uterine, and Female Infertility of Other Origin

• The selection of subjects' age must be group matched between protocols of treatment. Premature ovarian failure is defined as AMH (Anti Mullerian Hormone) ≤ 2 ng/mL.

• Willing to collaborate and to attend to the clinical follow-ups for the next three years

• Patients willing to sign informed consent

• Able and willing to comply with all study requirements

• Absence of genetic causes

• Medically suitable to undergo ovarian stimulation

• Normal serum chemistry and hematology screening tests

• Negative human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV) serology

• No history of malignancy

• Complete history & physical examination

Exclusion Criteria:

• Subjects to be excluded from the study if the male (husband) had any male infertility problem(s)

• Patients with any genetic abnormalities

• Patients with histories of neurologic conditions including moderate or severe head injury, stroke, cerebral or bone damage or malignancies, brain abnormalities, learning disability, major medical or psychiatric illness, and metabolic/cardiovascular disease or evidence of cardiac/renal damage or malignancies, alcohol, loss of weight during the last 2 years, chemotherapy or immunosuppressive therapy.

• Women aged 45 years and older, under 21 years