Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence

• Status: Completed
• Trial end date: 2005-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to compare the effect of manual based cognitive therapy in adjunct of three different pharmacotherapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Finnish Institute for Health and Welfare; National Institute for Health and Welfare, Finland
• Treatments: Acamprosate; Disulfiram; Naltrexone

Criteria

Inclusion Criteria:

• Alcohol dependence (ICD-10)

Exclusion Criteria:

• Clinically significant symptoms of alcohol withdrawal

• Significant recently diagnosed psychiatric disease (psychosis, personality disorder or suicidal tendency that appeared during the initial interview)

• Current psychiatric disease demanding special treatment or medication including DSM-IV determined drug dependence other than alcohol or nicotine dependence

• Current use of any opioids within four weeks before screening

• Significant brain, thyroid, kidney, uncompensated heart disease, or clinically significant liver disease (cirrhosis, aqlcoholic hepatitis or ALAT > 200)

• Pregnancy, nursing, or women refused to use a reliable method for birth control