Comparative the Effect of Metformin and Acupuncture on Weight Loss and Insulin Sensitivity

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators designed this randomized double blind (patients/ assessor) clinical trial to compare the therapeutic effects of Metformin monotherapy with Metformin and acupuncture combined therapy on weight loss and insulin sensitivity among overweight/obese type 2 diabetes mellitus (T2DM) patients. We compared the inflammatory markers, lipid profiles, and adipokines in overweight/obese T2DM patients receiving the combined therapy to those receiving the Metformin monotherapy, to understand whether acupuncture plus Metformin is a better approach then Metformin only on treating diabetes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Amir Firouzjaei
• Treatments: Insulin; Metformin

Criteria

Inclusion Criteria:

• Who had been diagnosed with type 2 diabetes mellitus and has using Metformin monotherapy as well to control their diabetes during the period of this study as previously (500 mg one/two/three times per day)

• All patients were overweight according to BMI ≥25

Exclusion Criteria:

• Individuals with nephritic syndrome (urine protein over 3.5 g/day), edema or renal failure (serum creatinine over 115 µmol/L)

• Individuals who had been diagnosed with heart failure (NYHA Fc III-IV) or who had been a pacemaker implanted

• Individuals with abnormal liver dysfunction (GOT and glutamate-pyruvate transaminase (GPT) levels twofold above the normal range) or a diagnosis of liver cirrhosis

• Individuals with a high HbA1C level (HbA1C above 9 %)

• Pregnant women

• Individuals who were receiving insulin therapy already

• Individuals who receive other therapy or had any change at dosage during the period of therapy

• Individuals who were suffering from endocrine abnormalities such as Thyroid disease, polycystic ovary syndrome (PCOS), etc

• Individuals who were receiving weight loss medicine, anti depressant agents' or hormonal medicines during the last 3 months and the period of study

• Individuals who were suffering from a homeostasis disorder or other systemic disease

• Individuals who did not comply(signed informed consent) with the treatment during the study period