Compare Between the Effect of Topical Tranexamic Acid Versus Hydrogen Peroxide on Blood Loss in Spine Surgeries

• Status: Active, not recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the effectiveness of topical TXA in reducing blood loss compared to H2O2 wash.

The primary outcomes :

1. Estimation of Intraoperative blood loss and blood transfusion.

2. Recording Postoperative blood drainage.

3. Comparing Hemoglobin levels (pre and postoperative).

The secondary outcomes :

1. Surgical site infection (SSI)

2. Length of hospital stay.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Minia University
• Treatments: Disinfectants

Criteria

Inclusion Criteria:

• ASA: class II or III

• Sex: male and female

• Age: from 20 to 70 years.

• Type of operation: patient will undergo spinal surgery with a diagnosis of in place spinal trauma, thoracic or lumbar degenerative disease, such as spinal canal stenosis, disc herniation, spondylolisthesis, and/or degenerative scoliosis under general anesthesia.

Exclusion Criteria:

• Patients with history of thromboembolic disease or coagulopathy or hereditary bleeding disorders such as factor VIII deficiency, factor IX deficiency, and Von-Willebrand disease.

• Patients who were taking anticoagulants or antiplatelet drugs.

• Allergy or hypersensitivity to TXA.

• A dural tear accompanied by cerebrospinal fluid leakage detected intraoperatively.

• Spinal cord tumors, head trauma and penetrating spinal cord trauma.

• The use of intravenous TXA during the perioperative period .

• Infection at the operative site e.g T.B.