Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer

• Status: Unknown status
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the gastric acid suppression profile among different regimen (Oral Vs Intravenous)of administration of proton pump inhibitor - Esomeprazole by 24hours intragastric pH monitoring.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pamela Youde Nethersole Eastern Hospital
• Treatments: Esomeprazole

Criteria

Inclusion Criteria:

1. Patients with non-bleeding peptic ulcer which do not require endoscopic therapy.

2. Chinese, Age ³18 and <90

3. Provision of an informed written consent signed by the patient.

Exclusion Criteria:

1. Treatment of antisecretory drugs during the preceding 4 weeks

2. The present inter-current ulcer complication (gastric outlet obstruction or ulcer perforation)

3. Presence of esophageal / gastric varices

4. aspirin or NSAID user

5. Pregnancy

6. Age <18 or >90

7. Moribund patients, patients with severe liver or renal disease

8. Known sensitivity to proton pump inhibitors

9. Previous gastric surgery (except simple patch repair)

10. Patient unable to give written consent

11. Special population, e.g. prisoner, mentally disabled, investigators' student or employees