Compare the Clinical Efficacy of Prototype Toothpastes

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Clinical study to compare the clinical efficacy of toothpastes on dental plaque and gingival inflammation.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colgate Palmolive
• Treatments: Fluorides; Listerine; Sodium Fluoride; Triclosan

Criteria

Inclusion Criteria:

• Male or female volunteers 18-65 years of age.

• Good general health.

• Must sign informed consent form.

• Minimum of 20 natural uncrowned teeth (excluding third molars) must be present.

• No history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study.

Exclusion Criteria:

• Subject unable or unwilling to sign the informed consent form.

• Medical condition which requires pre-medication prior to dental visits/procedures.

• Moderate or advanced periodontal disease.

• 5 or more decayed untreated dental sites at screening.

• Other disease of the hard or soft oral tissues.

• Impaired salivary function (e.g. Sjogren's syndrome or head and neck irradiation).

• Use of medications that currently affect salivary flow.

• Use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1.

• Pregnant or nursing women.

• Participation in any other clinical study within 1 week prior to enrollment into this study.

• Use of tobacco products.

• Subjects who must receive dental treatment during the study dates.

• Current use of Antibiotics for any purpose.

• Presence of an orthodontic appliance.

• History of allergy to common dentifrice ingredients.

• History of allergy to zinc.

• Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy).