Overview

Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

Status:
Withdrawn

Trial end date:
2016-08-01

Target enrollment:
0

Participant gender:
All

Summary

The purpose of this study is to compare the hemodynamic effects of a standardized induction of general anesthesia with either propofol or ketofol in patients with physical status classification ASA 3. The study will be a double blinded, randomized controlled trial (RCT) with two arms of treatment groups. One arm will consist of induction of general anesthesia using a mixture of 1.5mg/kg:0.75mg/kg Propofol/ketamine (ketofol) and the induction dose will be 1.5mg/kg of propofol and 0.75mg/kg of ketamine; the second arm will consist of induction of general anesthesia using propofol 2mg/kg. The primary outcome of the intervention will consist of hemodynamic changes during the first 30 minutes after induction of general anesthesia.

Phase:

Phase 2

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Yale University

Treatments:

Anesthetics
Ketamine
Propofol

Criteria

Inclusion Criteria:

- Patients age 18-80 scheduled for elective surgery

- Physical status ASA 3.

Exclusion Criteria:

- Patients with a physical status of ASA 1,2, 4 or 5,

- Prior adverse reaction to propofol, ketamine or both