Overview

Comparing Individualized vs. Weight Based Protocols to Treat VOE in SCD Occlusive Episodes in Sickle Cell Disease

Status:
Recruiting

Trial end date:
2022-09-30

Target enrollment:
0

Participant gender:
All

Summary

The purpose of this research study is to compare two different ways to give opioid pain medicine to treat sickle cell disease pain that is bad enough to go to the emergency department for treatment. One way uses your weight to decide how much pain medicine to give you while in the emergency department. This is called weight based treatment. The other way uses how much pain medicine you take at home and how much medicine you needed during past emergency department visits to decide how much medicine to give you. This is called patient specific treatment.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Duke University

Collaborator:

National Heart, Lung, and Blood Institute (NHLBI)

Treatments:

Analgesics
Hydromorphone
Morphine

Criteria

Inclusion Criteria:

- All adult (18 years or older);

- SCD patients with the following genotypes: Hgb SS, SC, and SB+ and SB- thalassemia

Exclusion Criteria:

- determined to not benefit from opioids and therefore won't receive opioids in any
future ED visit.