Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period

• Status: Recruiting
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study evaluates whether nifedipine or enalapril is better at decreasing the amount of medical resources used in the postpartum period by women who have high blood pressure in pregnancy and the postpartum period. Half of participants will receive enalapril while the other half will receive enalapril. We will compare the two groups in the amount of medical resources used which we are defining as prolonged hospitalizations, unscheduled medical visits and/or hospital readmissions in the postpartum period.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Antihypertensive Agents; Enalapril; Enalaprilat; Nifedipine

Criteria

Inclusion Criteria:

• diagnosis of any hypertensive disorder of pregnancy/postpartum period or chronic hypertension

• provider wanting to initiate antihypertensive in the postpartum period

• the patient is not currently on >1 antihypertensive

• plans to receive postpartum care at the hospital or affiliated clinic

Exclusion Criteria:

• sustained pulse <60 or >120 BPM over four hours

• allergy to any of the antihypertensives

• creatinine greater than or equal to 1.5

• strict contraindication to any of the antihypertensives

• history of failed treatment with any of the antihypertensives