Comparing Post-Operative Analgesic Effects of PCAM With Dexmedetomidine 1 mcg/ml vs PCAM With Dexmedetomidine 2 mcg/ml

• Status: Completed
• Trial end date: 2021-01-10
• Target enrollment: 0
• Participant gender: All

Summary

PCA morphine have been a common method in providing excellent analgesia for post-operative period. However, the usage of morphine is not without any side effects such as nausea, vomiting, respiratory depression, and over sedation.

Many adjunct have been used in combination with morphine to observe the opioid sparing effects at the same time providing good analgesia.

Dexmedetomidine is a potent and selective alpha-2 receptor agonist with sedative, anxiolytic, sympatholytic, and analgesic effects. As dexmedetomidine and morphine act via different mechanism, this combination produces synergistic analgesic effects.

The objective of our study was to observe the effectiveness in pain relief between two low concentration of dexmedetomidine (2 mcg/ml versus 1 mcg/ml) as an adjunct to PCA morphine 1 mg/ml.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universiti Kebangsaan Malaysia Medical Centre
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• ASA 1 & 2 patient

• going for elective or emergency laparotomy surgery

Exclusion Criteria:

• patient with known allergy to morphine or dexmedetomidine

• Creatinine clearance less then 30ml/min

• Current alcohol dependency

• Psychiatric illness on regular sedative-hypnotic drugs

• significant obstructive sleep apnoea (OSA)

• Chronic pain patient who on regular opioids