Comparing Postoperative Pain Following COX-2 and Prostanoids Expression

• Status: Unknown status
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare postoperative pain following COX-2 and prostanoids expression in women who underwent laparoscopic surgery for female genital disease in order to evaluate the effect of COX-2 on local inflammation, COX-2 and prostanoids expression followed by exposure time to carbon dioxide(CO2) gas, and degree of postoperative pain.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Cyclooxygenase 2 Inhibitors

Criteria

Inclusion Criteria:

• Female, Age ≥ 20 years

• Patients with benign female genital disease who need laparoscopic surgery

• Patients with benign disease who can be treated by single port laparoscopy

• Patients who signed an approved informed consent

Exclusion Criteria:

• Female, Age < 20 years

• Pregnancy

• Previous cancer history

• Patients who refuse to sign an informed consent

• Patients with benign female genital disease combined clinical peritonitis (ex. tubo-ovarian abscess, tubo-ovaritis, ruptured endometriosis)

• Patients with malignant female genital disease

• Patients who got surgery with multi-port laparoscopy

• Patients who are contraindicated with COX-2 inhibitors (liver disease, renal disease, active peptic ulcer, active gastrointestinal tract bleeding, ischemic heart disease, hyperkalemia)