Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Many patients in the hospital who are malnourished or not eating received intravenous feeding
or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk
of infections and hospital complications. We do not know why TPN increases hospital
complications, but it may be caused by the high sugar or fat content in TPN solutions. The
investigators believe that the high sugar and high fat content can limit the ability to fight
infections and produce stiffness of blood vessels. This study will compare the effect of high
sugar, high fat content or both on blood sugars, blood vessel function, on blood vessel
function. The investigators will also compare the effect of different fats (olive oil and
soybean) in the TPN solution on the risk of infection and blood vessel function on a total of
12 healthy subjects.