Overview

Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis

Status:
Completed
Trial end date:
2019-01-25
Target enrollment:
0
Participant gender:
All
Summary
This is a three-week crossover study that will compare how the body absorbs and tolerates two different forms of lipoic acid: R form and racemic form.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Rebecca Spain
Treatments:
Thioctic Acid
Criteria
Inclusion Criteria:

- Diagnosis of Progressive Multiple Sclerosis

- 18 years of age or older

- Able to give informed consent and adhere to the study activities

- Able to swallow large oral capsules

Exclusion Criteria:

- Clinical Multiple Sclerosis relapse in the prior 1 year

- Oral or IV steroids in the prior 3 months

- Have taken LA in last 30 days

- Clinically significant kidney disease as determined by the PI including, but not
limited to, major kidney disease diagnoses, abnormal laboratory values related to
renal function, or other related conditions

- Insulin-dependent diabetes

- Other significant ongoing medical illness that may interfere with study procedures

- Taking oral anticoagulants (e.g. Coumadin). Aspirin, clopidogrel, and dipyridamole are
acceptable to take

- Pregnant or breast-feeding

- Any condition which would make the patient, in the opinion of the investigator,
unsuitable for the study