Comparing Tricor, Avandia, or Weight Loss to Lower Cardiovascular Risk Factors in People With High Triglycerides.
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
Approximately 1/4 of the US population has insulin resistance and the associated risk factors
such as elevated lipid levels -triglycerides (type of fat from what we eat and what the liver
produces and low HDL cholesterol which is the good cholesterol helping to protect against
heart disease. Currently one known treatment for this a medication called fenofibrate,
another medication that can improve insulin resistance is rosiglitazone, a third treatment
known to improve insulin resistance an decrease triglycerides is weight loss. In this study
insulin resistant individuals with elevated triglycerides and or a ratio of triglycerides to
HDL cholesterol of 3:1 or greater will be randomized (selected by chance) to receive one of
these treatments and results of insulin sensitivity and cardiac risk profiles will be
compared at the end of the study.