Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in Elderly

• Status: NOT_YET_RECRUITING
• Trial end date: 2025-12-01

Summary

Hip surgery in the elderly is commonly performed under spinal anesthesia, which is associated with a lower risk of postoperative complications. However, this population is highly susceptible to postspinal hypotension-occurring in up to 69% of cases-which can compromise organ perfusion and increase the risk of organ failure and mortality. Vasodilation-induced hypotension is typically managed with vasopressors, and norepinephrine, with both - and weak -agonist activity, has recently been introduced as a prophylactic agent in this setting. Prior research demonstrated that a norepinephrine infusion at 0.1 mcg/kg/min effectively prevented hypotension in elderly patients undergoing hip arthroplasty, but only one dose was tested. Given findings from obstetric studies suggesting lower effective doses, the current study aims to determine whether a lower infusion rate (0.07 mcg/kg/min) is non-inferior to the higher dose in maintaining intraoperative blood pressure. Identifying the optimal dose is important for minimizing drug exposure while ensuring hemodynamic stability.

• Phase: NA

Details

• Lead Sponsor: Kasr El Aini Hospital
• Treatments: Norepinephrine