Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The effectiveness of medications in cardiac arrest has been greatly debated and questioned. Historically intravenous adrenaline has been the drug of choice since 1906. There have been few formal evaluations to determine the value of adrenaline for cardiac arrest, and clinical trials have not been able to show any benefit with intravenous adrenaline (compared to placebo or no treatment) in the field.

Thus the purpose of this study is to compare vasopressin and adrenaline in the treatment of cardiac arrest to answer the question whether there is an improvement in survival between vasopressin and adrenaline.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Singapore General Hospital
• Collaborators: Alexandra Hospital; Alexandra Hospital, Singapore; Changi General Hospital; National Medical Research Council (NMRC), Singapore; National University Hospital, Singapore
• Treatments: Arginine Vasopressin; Epinephrine; Epinephryl borate; Racepinephrine; Vasopressins

Criteria

Inclusion Criteria:

• Patient with cardiac arrest as confirmed by the absence of a pulse, unresponsiveness and apnea

• Age above 16 (Age 21 and above for CGH only)

Exclusion Criteria:

• Traumatic cardiac arrest

• Age 16 and below (Age 20 and below for CGH only)

• CPR is contraindicated