Comparing of Cefazolin Plus Azithromycin Versus Cefazolin in Prevention of Febrile Morbidity After Emergency Cesarean Delivery

• Status: Not yet recruiting
• Trial end date: 2023-12-30
• Target enrollment: 0
• Participant gender: Female

Summary

Cesarean section is the common surgery in world wide. But the complication like febrile morbidity such as surgical site infection, fever, urinary tract infection and endometritis can be occurred even giving the standard antibiotics. Therefore if wider bacterial spectrum coverage antibiotic like azithromycin is added to the standard antimicrobial prophylaxis(1st generation cephalosporin), the incidence of febrile morbidity could be reduced. We will compare the regimen of cefazolin plus azithromycin and standard regimen of cefazolin alone in prevention of febrile morbidity after emergency cesarean section.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rajavithi Hospital
• Treatments: Azithromycin; Cefazolin

Criteria

Inclusion Criteria:

1. Singleton pregnancy with a gestation of 24 weeks or more

2. Undergoing non-elective cesarean delivery during labor or rupture of membrane more than 4 hr

3. No allergy to macrolide such as azithromycin and clindamycin

4. Provide informed consent

5. Partner of participant allows the patient to participate the research

Exclusion Criteria:

1. Use of azithromycin within 7 days before enrollment

2. Chorioamnionitis or other infection requiring postpartum antibiotic therapy (except for antibiotics for group B streptococcus)

3. Liver disease (Cirrhosis or AST more than 3 times the upper normal limit)

4. Serum creatinine level of more than 2.0 mg/dL or need dialysis

5. Diarrhea at the time of enrollment

6. Maternal heart disease

7. Use of medication known to prolonged the QT interval