Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat

• Status: Completed
• Trial end date: 2021-02-07
• Target enrollment: 0
• Participant gender: All

Summary

A prospective randomized double-blind study including patients ASA I-II, aged more than 18 years undergoing surgery under general anesthesia (GA) and endotracheal intubation. Patients were randomized allocated into 2 groups: ketamine group received ketamine gargle (0.5 mg/kg up to 30 ml dextrose water) and magnesium group received magnesium sulfate gargle (20 mg/kg up to 30 mL dextrose water ) 15 minutes before the operation.

Our primary outcome is sore throat and the secondary judging criteria are cough, dysphonia and satisfaction. A standardized anesthesia protocol was followed for all patients. After extubation, the patients were asked to grade POST, hoarseness, and cough at 15 min, 1h, and 24 h.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Tunis El Manar
• Treatments: Ketamine; Magnesium Sulfate

Criteria

Inclusion Criteria:

• age is greater than or equal to 18 years

• ASA class 1 or 2

• patients proposed for elective visceral, orthopedic, oncology, ophthalmologic, urologic surgery under general anesthesia with orothracheal intubation

Exclusion Criteria:

• known allergy to ketamine or maguisuim sulphate

• ASA 3 and more

• cervical surgery

• difficult intubation planned or history of difficult intubation

• malformation of the O.R.L sphere

• the need for multiple laryngoscopies for orotracheal intubation (≥ 2 attempts);

• the need for a postoperative nasogastric tube.