Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars

• Status: Recruiting
• Trial end date: 2024-11-14
• Target enrollment: 0
• Participant gender: All

Summary

This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches. These patches comprising short microneedles embedded with hydrolysed RNA (siRNAs) have been classified by Health Science Authority, Singapore, as cosmetic products.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Skin Centre

Criteria

Inclusion Criteria:

• Adult

• Age 21-75

• 2 weeks (+/- 7 days) after surgical operation with incision into the dermis

• Post-stitch removal when stitches were applied

• Wound closure/union achieved

Exclusion Criteria:

• Pregnant or lactating participant

• Participants with wound infection

• Participants assessed to be uncooperative or unable to self-administer the interventions

• Participants with known contact allergy to ingredients in the patch formulation (comprising hyaluronic acid, siRNA and glue) and/or isopropyl alcohol

• Participants who are unable to personally consent (for e.g., cognitively impaired)