Comparing the Effectiveness of Combined NRT With Single NRT in Primary Care Clinics in Hong Kong
Status:
Completed
Trial end date:
2018-02-28
Target enrollment:
Participant gender:
Summary
The prevalence of cigarette smoking has dropped to 10% in Hong Kong (HK) in 2017, however,
smoking still kills 5700 persons per year. Studies suggest that abstinence rates are higher
with combined NRT than single NRT, although local data on safety and benefits of combined NRT
are lacking.
This is a one-year, two-arm, parallel randomized trial in 20 HK public clinics. The aim is to
compare the effectiveness of combined NRT with single NRT among HK Chinese. 560 chronic
smokers, who smoked ≥10 cigarettes/day for ≥ 1 year, were randomized to either intervention
or usual care.
Intervention group received counseling and nicotine patch & gum. Usual care group received
counselling and nicotine patch only. Primary outcome was smoking abstinence rate at 52 weeks.
Secondary outcomes included smoking abstinence rate at 4, 12, & 26 weeks. Crude odds ratio
(combined NRT vs. single NRT) and p-value were reported from logistic regression without
adjustment; for trend analysis, adjusted odds ratio (AOR) and p-value were reported from
Generalized Estimating Equation (GEE) (controlling for time). All AORs were adjusted for age,
sex, baseline CO and clusters.