Overview

Comparing the Efficacy of Tacrolimus and Mycophenolate Mofetil for the Initial Therapy of Active Lupus Nephritis

Status:
Completed

Trial end date:
2014-06-01

Target enrollment:
0

Participant gender:
All

Summary

The purpose of this study is comparing the efficacy of tacrolimus and mycophenolate mofetil for the initial therapy of active lupus glomerulonephritis.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Tuen Mun Hospital

Treatments:

Mycophenolate mofetil
Mycophenolic Acid
Tacrolimus

Criteria

Inclusion Criteria:

1. Patients who fulfill at least 4 of the ACR criteria for SLE

2. Age >= 18 years

3. Biopsy proven active lupus glomerulonephritis (ISN/RPS class III/IV/V)

4. Serum creatinine < 200 umol/L at the time of randomization

Exclusion Criteria:

1. Patients who refuse to be randomized for treatment

2. Patients who prefer treatment with conventional agents such as oral or intravenous CYC
for various reasons

3. Serum creatinine >= 200 umol/L at the time of randomization

4. Patients without renal biopsy or those who have lupus nephritis ISN/RPS class I,II,VI

5. Patients who are pregnant or plan for pregnancy within 12 months after randomization