Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus

• Status: Not yet recruiting
• Trial end date: 2026-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare efficacy and safety of paracetamol and ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in preterm infants.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• preterm infants

• with gestational age ≤37weeks

• who had echocardiographically confirmed significant PDA.

Exclusion Criteria:

• Preterm neonates

• with major congenital anomalies,

• life threatening sepsis,

• NEC,

• IVH,

• urine output <1ml/kg/h in the last 24 h,

• serum creatinine concentration >1.5 mg/dl, -platelet count <100,000/ml,

• complex congenital heart,

• or duct-dependent lesions.