Comparision Efficacy of Carbamazepine & Oxcarbazepine in the Treatment of Trigeminal Neuralgia- a Randomised Clinical Trial

• Status: Recruiting
• Trial end date: 2022-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Trigeminal neuralgia is a neuropathic facial pain condition, characterized by unilateral paroxysmal pain which can be described as stabbing or electric shock like, in the distribution of one or more divisions of trigeminal nerve which is triggered by innocuous stimuli. The attack is provoked by touching or stimulating these trigger zones. There are various pharmacological drugs present for the treatment of trigeminal neuralgia. Carbamazepine and oxcarbazepine are the first-choice drugs for the treatment of TN. Other drugs include lamotrigine , baclofen , gabapentin, antidepressants , eslicarbazepine , sumatriptan & vixitrigine. The carbamazepine is first choice of drug which has serious side effects including dizziness, memory loss, sleppiness, aplastic anaemia. Oxcarbazepine has similar mechanism of action and found to have lesser adverse events when used in various neuralgias in the place of carbamazepine. But there is still lack of evidence to prove that oxcarbazepine can be used as monotherapy in TN patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Postgraduate Institute of Dental Sciences Rohtak
• Treatments: Carbamazepine; Oxcarbazepine; Zileuton

Criteria

INCLUSION CRITERIA:

• Clinically proven cases of primary trigeminal neuralgia.

• Patients who are willing to participate in the study.

EXCLUSION CRITERIA:

• Intolerance to either of the two drugs

• Medically compromised patients

• Patients with pacemaker

• Patients who have previously undergone surgical treatment for TRIGEMINAL NEURALGIA.

• Patients who are already on pharmacotherapy for TRIGEMINAL NEURALGIA.

• Seizure disorder/ pregnant/ lactating

• Renal/ hepatic impairment

• History of hyponatermia

• Concurrent medication- dilantin, phenytoin