Comparison Between Asymmetric And Standard Split-Dose Regimen For Bowel Preparation
Status:
Completed
Trial end date:
2017-05-05
Target enrollment:
Participant gender:
Summary
We aimed to compare the efficacy for bowel cleansing of a split-dose regimen with a low
morning dose of PEG solution (Asymmetric; 25% of the dose is given on the day of the
procedure and 75% of the dose is given on the day before) with the standard split-dose
regimen in patients undergoing screening and surveillance colonoscopy using a low volume
bowel preparation (2L PEG-citrate-simethicone plus Bisacodyl). We enrolled consecutive
outpatients undergoing screening and surveillance colonoscopy in a randomized, single-blind,
non-inferiority clinical trial. Patients were randomly assigned to: group A, asymmetric split
dose regimen (1,5 L of PEG + bisacodyl the day before and 0,5 L 4 hours before colonoscopy);
group B, symmetric split dose regimen (1 L of PEG + bisacodyl the day before and 1 L 5 hours
before colonoscopy). Primary endpoint was the proportion of adequate bowel cleansing.
Moreover, all patients filled in a nurse-administered questionnaire assessing compliance,
tolerability and safety of bowel preparation.