Comparison Between Asymmetric And Standard Split-Dose Regimen For Bowel Preparation

• Status: Completed
• Trial end date: 2017-05-05
• Target enrollment: 0
• Participant gender: All

Summary

We aimed to compare the efficacy for bowel cleansing of a split-dose regimen with a low morning dose of PEG solution (Asymmetric; 25% of the dose is given on the day of the procedure and 75% of the dose is given on the day before) with the standard split-dose regimen in patients undergoing screening and surveillance colonoscopy using a low volume bowel preparation (2L PEG-citrate-simethicone plus Bisacodyl). We enrolled consecutive outpatients undergoing screening and surveillance colonoscopy in a randomized, single-blind, non-inferiority clinical trial. Patients were randomly assigned to: group A, asymmetric split dose regimen (1,5 L of PEG + bisacodyl the day before and 0,5 L 4 hours before colonoscopy); group B, symmetric split dose regimen (1 L of PEG + bisacodyl the day before and 1 L 5 hours before colonoscopy). Primary endpoint was the proportion of adequate bowel cleansing. Moreover, all patients filled in a nurse-administered questionnaire assessing compliance, tolerability and safety of bowel preparation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: ASST Rhodense
• Treatments: Bisacodyl; Citric Acid; Simethicone

Criteria

Inclusion Criteria:

• All patients scheduled as outpatient for screening or surveillance colonoscopy

Exclusion Criteria:

• Inpatients

• refusal of split dose regimen for bowel preparation

• previous history of colorectal resection

• severe cardiac disease

• advanced (stage IV and V) chronic kidney disease

• pregnancy; ileus

• suspected bowel obstruction or toxic megacolon

• known inflammatory bowel disease

• known or suspected allergy to PEG.