Comparison Between Lactulose and Lactulose-Paraffin in Cirrhotic Patients

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Hepatic encephalopathy (HE) is an important complication of liver cirrhosis. Lactulose is a first line treatment for HE, but the adherence to this treatment is relatively low, due to side effects such as diarrhea, distention, etc.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
• Treatments: Lactulose

Criteria

Inclusion Criteria:

• Liver cirrhosis

• History of an event of hepatic encephalopathy.

• Ambulatory patients

Exclusion Criteria:

• Alcoholism with active ingest of alcohol in the last 6 months

• Labour turn-overs

• Pregnancy

• Personal history of surgery in the last 4 weeks

• Spontaneous bacterial Peritonitis

• Use of neuropsychiatric drugs

• Neuropsychiatric disorders (Schizophrenia, bipolar disorder, major depression, dementia and Attention-deficit hyperactivity disorder)

• Thyroid disorders without replacement therapy

• Renal failure

• Hepatic or renal transplant

• Personal history of hepatocellular carcinoma

• Placement of transjugular intrahepatic portosystemic shunt

• Use of a probiotic in the last 6 month