Comparison Between Losartan and Benazepril in Diabetic Hypertensive Patients Not Controlled by Amlodipine

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare losartan and benazepril in diabetic patients whose high blood pressure is not controlled by amlodipine and its relationship to statin current use.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Universitario Pedro Ernesto
• Treatments: Amlodipine; Benazepril; Losartan

Criteria

Inclusion Criteria:

• Ambulatorial patients with age between 40 and 70 years-old.

• Systemic arterial hypertension previously diagnosed and in use of two or less anti-hypertensive drugs in the preceding 4 weeks.

• Type 2 diabetes mellitus in use of oral medication that were not changed in the preceding 4 weeks. Glycated hemoglobin A1c less than 9.0%.

• Accepted the consent form.

Exclusion Criteria:

• Office systolic blood pressure equal or more than 180 mmHg, with or without treatment

• Office diastolic blood pressure equal or more than 110 mmHg, with or without treatment

• Evidences of a secondary cause for hypertension

• Glycated hemoglobin A1c > 9.0%

• Insulin therapy

• Chronic kidney disease stage 4 or 5 or in dialysis

• Advanced target organ lesion, obtained by history or additional exams, and defined by:

previous myocardial infarction, heart failure with ejection fraction less than 40%, cerebral vascular accident (ischemic or hemorrhagic), peripheral vascular disease (claudication or doppler with obstruction > 50% of vascular lumen), retinopathy with visual loss, symptomatic neuropathy.

• Cardiac arrhythmias, except for ectopic beats

• Any clinical or disabling condition that, in the opinion of the investigators, may confound or prejudice study results.

• Severe mitral regurgitation.

• Women in fertile age without contraceptive methods in use.

• Breastfeeding women.