Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate whether or not marijuana blunts will produce comparable plasma THC levels as marijuana joints and if blunts will produce larger cardiovascular and subjective effects.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: New York State Psychiatric Institute
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Naltrexone

Criteria

Inclusion Criteria:

• Current blunt marijuana use (minimum of twice/week) drug screen

• 21-45 years of age

• Practicing an effective form of birth control (condoms, diaphragm, birth control pill, IUD)

Exclusion Criteria:

• Current, repeated illicit drug use(excluding marijuana)

• Heavy cigarette use (> 10 cigarettes/day)

• Presence of significant medical illness (e.g., diabetes, cardiovascular disease, hypertension)

• Laboratory tests outside normal limits that are clinically unacceptable to the study physician (BP > 140/90; hematocrit < 34 for women, < 36 for men)

• Significant adverse reaction to marijuana

• Current parole or probation

• Pregnancy or current lactation

• History of significant violent behavior

• Major current Axis I psychopathology(e.g., mood disorder with functional impairment or suicide risk, anxiety disorder, schizophrenia)

• History of heart disease

• Current use of any over-the-counter or prescription