Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia

• Status: Enrolling by invitation
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The research will be conducted between March 2021 and June 2023. All patients scheduled electively for one of four surgeries (Laparoscopic Cholecystectomy, Submucosal resection, Breast lumpectomy, and median laparotomy) at that period of time at An-Najah National University hospital will be included in the research sample, unless not meeting with the criteria put.

Primary objectives are:

To evaluate the effectiveness of preemptive analgesia on postoperative pain relief and shorter hospital stay for adults undergoing surgical procedures, according to the type of surgery and the type of drug.

To compare the effect of a single oral preemptive dose of Pregabalin versus Oxycodone on postoperative pain relief, in terms of pain intensity as assessed by pain numeric rating scale (NRS)

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: An-Najah National University
• Treatments: Oxycodone; Pregabalin

Criteria

Inclusion Criteria:

1. Age > 18-year-old.

2. Patients undergoing elective surgeries under general anesthesia.

3. American Society of Anesthesiology grade 1 or 2.

4. BMI 18-35 Kg/m2

5. Reliable participant (he/she can give history by him/herself)

Exclusion Criteria:

1. Current Pregnancy or breastfeeding.

2. Chronic use of analgesia (use of any analgesic drug for most days in the last three months).

3. Current use of analgesia (within last 24 hours).

4. Allergy to any medication used in the study.

5. Smoking or Nargila use within last 24 hour before surgery and until discharge.

6. History of psychiatric medication or disease.

7. Discharge from hospital within 6 hours after surgery.

8. Participants transferred from the ward to ICU or other wards.

9. Known case of liver or kidney impairment.

10. History of alcohol use or illicit drug.

11. Any complication during surgery leads to changes in protocol of the study.