Comparison Between Platelet-rich Fibrin and Steroid for Intra-articular Injection for Sacroiliac Joint Dysfunction
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
Low back pain is one of the commonest complaints nowadays affecting nearly 20% of the
population, Sacroiliac joint has been accused of being the primary cause of pain in about
10%: 27% of this population.
The sure diagnosis of sacroiliac joint pain is challenging because of multiple crossed
factors of facet joint pain and intervertebral disc pain. Diagnosis can be done by history
taking, local examination, imaging techniques, and controlled local anesthetic blocks.
Controlled local anesthetic blocks are diagnostic and therapeutic done by various methods
either landmark-guided or imaging-assisted either by fluoroscopy, computed tomography (CT),
magnetic resonance (MRI), or ultrasound-guided.
Lower cost, real-time viewing of needle leading to higher accuracy rate, and low ionizing
radiation dose are favoring ultrasound-guided injection over other modalities.
Numerous treatment modalities are being used for sacroiliac joint pain ranging from
physiotherapy and systemic analgesics like Non-steroidal anti-inflammatory drugs (NSAIDs) to
minimally invasive intra-articular, periarticular injection, radiofrequency neurotomy, and
surgical fusion of the joint.
Multiple injectates are being used for intraarticular injection most commonly local
anesthetics and steroids which offer short-term symptomatic relief and delay the degenerative
process.
The need for a longer duration effect directly affects the disease process itself aiming for
accelerating the joint healing rate by biological growth factors found in human blood
especially in platelets.
Platelet-rich plasma (PRP) has been used aiming to inject a high concentration of growth
factors directly into the joint.
Platelet-rich fibrin (PRF), the second generation of platelet-rich plasma is now tried having
the advantage of a simpler preparation and higher values of growth factors.