Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular Cohort
Status:
Unknown status
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
In vitro fertilization(IVF) with Gonadotropin-releasing hormone (GnRH) antagonist is one of
the most used protocol for the treatment of infertile couples nowadays. Despite several
advantages over GnRH agonist, the antagonist may be associated with a slightly reduction in
pregnancy rates.
Several medications have been tested in order to increase ovarian response to ovulation
induction, including estradiol and testosterone. A clinical trial in women with IVF
indication will be performed and this women will be randomly assigned to receive topic
testosterone, oral estradiol or no pre-treatment prior to IVF with human Chorionic
Gonadotropin (hMG) and GnRH antagonist. The primary endpoint will be the size and number of
follicles on the beginning of the cycle, after pre-treatment.