Comparison Between Two Different Antibiotic Regimens for the Placement of Dental Implants
Status:
Completed
Trial end date:
2017-05-01
Target enrollment:
Participant gender:
Summary
In order to prevent infections and complications, it has been initially established with the
dental implant placement protocol that pre- and post-operative antibiotics should be
prescribed to the patient receiving dental implants. There have been many antibiotic regimens
used in the attempt to minimize the risks of infections and consequently, increasing the
survival rate of dental implants placement procedures. However, issues about bacterial
resistance have been raised recently concerning the extensive use of antibiotics. The primary
objective of this study is to find out whether giving antibiotics before or after implant
placement would significantly influence crestal bone loss around dental implants. One study
group will receive one dosage of antibiotics before implant placement followed by
post-operative intake of antibiotics for 7 days. Another group will receive the antibiotics
in one single preoperative dose followed by an identical placebo for 7 days. Questionnaires
for pain and interference with daily activities assessment to be filled for the first
postoperative week will be distributed to participants. Signs of postoperative morbidity will
be recorded at 1 and 3 weeks following the surgery, and both clinical and radiographic data
will be collected at 4 months postoperative to assess the implants status. A radiographic
follow-up will be done 1 year after the surgery. Peri-implant crevicular fluid levels of 3
known immunological markers for bone loss (MMP-8, sRANKL and OPG) will be measured at 1-, 3-
and 16-weeks follow-ups. The findings from this study might allow clinicians to establish the
ideal antibiotic regimen with minimal risk exposure to bacterial resistance.