Comparison Between Two Drugs (Propofol and Nitroglycerin as a Hypotensive Agents During Endoscopic Sinus Surgery
Status:
Terminated
Trial end date:
2020-02-12
Target enrollment:
Participant gender:
Summary
Background and Objectives: FESS is a common minimally invasive surgery that requires a clear
field to be performed well. Hypotensive anesthesia is one of the most common maneuvers
performed to help in keeping the field clear. An ideal drug for hypotensive anesthesia should
be cheap and familial to the anesthesiologist. So being familial with propofol and by using
its cardio-depressant action the idea of the research was developed and comparing it with
nitroglycerin (a hypotensive agent in our protocol). Methods: The patients agreed to
participate in the research were classified into two groups for comparison. Propofol group;
received propofol infusion all over the procedure, and nitroglycerin group; received
nitroglycerin infusion all over the procedure. Duration of surgery, visibility of surgical
field and amount of blood loss were recorded. Pulse/min and MAP were recorded at baseline and
every 5 min. Results: The mean duration of surgery was longer in the NTG to propofol group.
There was high statistical significance in the average blood loss in the propofol group
compared to NTG group. The visibility of the operative field also was significant in the
propofol group as compared to NTG group. The mean heart rate in the NTG group is higher than
the mean heart rate in the propofol group. The MAP in both groups is within a close range.
Conclusion: Propofol and NTG can produce a safe and effective controlled hypotension during
FESS. Whereas, propofol has; a better surgical field visibility, less surgical bleeding and
less tachycardia during FESS.