Comparison Between Two Types of Sedation for Elective Upper Endoscopy Procedures

• Status: Completed
• Trial end date: 2019-11-30
• Target enrollment: 0
• Participant gender: All

Summary

Sedation is defined as the act of administrating a sedative drug to produce a state of calm or sleep. Sedation is commonly given to a patient in hospital settings to provide a tolerable and pleasant experience by relieving anxiety, pain and discomfort, as well as to expedite the duration of the procedure. Moderate sedation (conscious sedation) is the preferred state of sedation, whereby self-maintenance of ventilation and hemodynamic stability is achieved.

The primary objective of this study is to determine if inhalational Sevoflurane is a more superior sedative agent in terms of faster psychomotor recovery and time taken to fulfil discharge criteria when compared with intravenous Midazolam sedation.

Secondary objective is to determine if inhalational Sevoflurane sedation has better patient's and endoscopist's satisfaction when compared with intravenous Midazolam sedation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Malaya
• Treatments: Midazolam; Sevoflurane

Criteria

Inclusion Criteria:

• ASA I to II

• Patients who are not taking sedative agents prior to procedure.

• Patients who are able to give consent for the procedure.

Exclusion Criteria:

• Patients with ischaemic heart disease, respiratory diseases and cerebrovascular disease.

• Patients who are taking opioid or sedative medications 24 hours before procedure.

• Patients with previous history of adverse effects to Sevoflurane or Midazolam.

• Pregnant patients.

• Patients with airway obstructions.

• Patients with features of difficult airway such as limited neck extension, small mouth opening of less than 3 cm, mallampati score of more than 3.

• Patients who are at risk of aspiration. Impaired gag reflex, presence of neurological disorders and impaired physical mobility.