Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections

• Status: Not yet recruiting
• Trial end date: 2024-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Genicular nerve neurolysis (GN) constitutes a relatively novel technique, whereby different chemical compounds (i.e. alcohol, phenol) are injected in close proximity to the genicular nerves of the knee joint, with the intention to exert a neurolytic effect by denaturing proteins resulting in Wallerian degeneration distal to the lesion. Based on the preliminary evidence and considering the potential benefits of the technique, we hypothesized that ultrasound-guided genicular chemical neurolysis with phenol is superior in terms of pain relief at 3 months, when compared to intra-articular steroid (IAS) injection.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Manitoba
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Phenol; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Severe knee pain for more than 6 months, defined as Numeric rating scale (NRS) score of 6 and greater, unresponsive to conservative medical treatment

• Radiological OA grade 2 to 4 (Kellgren-Lawrence scale)

Exclusion Criteria:

• Previous total knee replacement on the index knee

• Prior knee radiofrequency ablation on the index knee

• Connective tissue diseases with knee involvement (e.g. rheumatoid arthritis)

• Body mass index ≥ 40 kg/m2

• Uncontrolled coagulopathy, defined as supratherapeutic dose of anticoagulation medication

• Allergy to local anesthetics

• Unstable opioid consumption, defined as an increase >10% in dosage during the last 3 months prior to recruitment.