Comparison Efficacy of 14-day Concomitant Therapy:Clarithromycin vs.Levofloxacin in Eradication of H.Pylori

• Status: Withdrawn
• Trial end date: 2022-01-31
• Target enrollment: 0
• Participant gender: All

Summary

Comparison Efficacy of 14-day Concomitant therapy between levofloxacin and Clarithromycin on the Eradication of Helicobacter Pylori in Syrian population

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Damascus Hospital
• Treatments: Amoxicillin; Clarithromycin; Esomeprazole; Levofloxacin; Ofloxacin; Tinidazole

Criteria

Inclusion Criteria:

-Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods: I-Positive rapid urease test (CLOtest). II-Histologic evidence of H. pylori by modified Giemsa staining. III-Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.

Exclusion Criteria:

• Children and teenagers aged less than 18 years.

• Previous eradication treatment for H. pylori.

• Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics.

• History of gastrectomy.

• Gastric malignancy, including adenocarcinoma and lymphoma,

• Previous allergic reaction to antibiotics (Amoxicillin, Tinidazole , Levofloxacin) and prompt pump inhibitors (Es-omeprazole).

• Contraindication to treatment drugs.

• Pregnant or lactating women.

• Severe concurrent disease. Liver cirrhosis. Chronic kidney disease.

• Patients who cannot give informed consent by himself or herself.