Comparison of 12% Ammonium Lactate and 10% Urea Cream in Geriatric With Xerosis Cutis

• Status: Completed
• Trial end date: 2017-05-31
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to compare the efficacy and safety between moisturizing cream containing 12% ammonium lactate and 10% urea in geriatric with xerosis cutis. A double-blind randomized controlled trial with matching paired subject was conducted on 40 residents of a nursing home in Jakarta. Specified symptom sum score (SRRC), skin capacitance (SCap), transepidermal water loss (TEWL), and side effects were measured at baseline, week-2 and week-4 after therapy, and week-5 one week after therapy cessation. After a week of preconditioning, each subject received two different moisturizing creams to be applied on separate lower limbs.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indonesia University
• Treatments: Carbamide Peroxide

Criteria

Inclusion Criteria:

• presenting with clinical diagnosis of xerosis cutis or with using the specified symptom sum score (SRRC)

• able to communicate well and perform daily activities independently

• willing to follow the research and sign the informed consent

Exclusion Criteria:

• sensitive to the ingredients in the formulations

• suffer from dermatitis or skin inflammation at the test site

• erythema and fissure values based on SRRC value >2