Comparison of Alendronate With Atorvastatin in Chronic Periodontitis

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of two local drug delivery systems containing 1% ALN gel and 1.2% ATV gel in treatment of intrabony defects in patients with chronic periodontitis as an adjunct to SRP.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Government Dental College and Research Institute, Bangalore
• Treatments: Alendronate; Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Systemically healthy patients with PDs ≥5mm or CALs ≥4 to 6mm and vertical bone loss ≥3 mm on intraoral periapical radiographs with no history of periodontal therapy or use of antibiotics in the preceding 6 months were included

Exclusion Criteria:

• Patients with a known systemic disease;

• known or suspected allergy to the ALN/bisphosphonate group and ATV/statin group;

• on systemic ALN/bisphosphonate and therapy ATV/statin group;

• with aggressive periodontitis;

• who used tobacco in any form;

• alcoholics;

• immunocompromised patients;

• and pregnant or lactating females were excluded from the study