Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
ICU patients often in a strong stress environment. Various invasive procedures such as wound
dressing change, sputum suction,Pull out the thoracic duct etc. At the same time, the
diseases and environmental factors caused patients anxiety, pain, delirium and even a series
of pathophysiological changes which harm life and safety. Fentanyl is an analgesic that acts
on central μ receptors, clinical practice had found that fentanyl could exert analgesic
effects, while it maybe affect patients' hemodynamics, breathing, and nervous system, which
caused hypotension, bradycardia, respiratory depression, delirium and other adverse drug
reactions. These reactions prolonged the mechanical ventilation time and duration time of
patients in hospital, which impact the treatment effect and prognosis of patients.
Butorphanol tartrate is a new type of opioid receptor agonist and antagonist, which can
stimulate the κ receptor, and also certain stimulated and antagonised effects on the μ
receptor. It can be used for analgesia and sedation in patients of ICU. Previous studies
shown that butorphanol can inhibit the inflammatory response and effect myocardial
protective. The analgesic effect of butorphanol were equivalent to fentanyl in patients of
ICU, and the incidence of nausea and vomiting in participants with butorphanol less than
fentanyl. Therefore, the investigators speculate that the analgesia of butorphanol in ICU
patients may unexpected effects. However, butorphanol and fentanyl on the analgesic effect
and prognosis of patients with mechanical ventilation in ICU are lacking currently, and the
investigators no corresponding multi-center clinical study at home and abroad. The research
compare to the analgesic effect of butorphanol and fentanyl in critically ill patients with
mechanical ventilation. Effects of butorphanol and fentanyl on mechanical ventilation
duration, sedation depth, duration time of patients in hospital, complications and mortality
in patients with mechanical ventilation. To analyze the high-risk factors affecting the
prognosis of patients with mechanical ventilation in ICU. Found more treatment measures for
analgesia of patients with mechanical ventilation in ICU.