Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
Fast awakening from anesthesia is one of the major characteristics of remifentanil-associated
anesthetic induction and maintenance, whereas corresponding pain during awakening influences
patient's rehabilitation strongly. In addition, such early postoperative pain results in
significant stress responses, which displays as further release of stress hormones such as
cortisol and β-endorphin as well. How to prevent such acute pain resulting from
remifentanil's fast metabolism endows clinical significance. This study is designed to
compare the analgesic efficacy of fentanyl, sufentanil and butorphanol delivered after
gynecological laparoscopic surgeries that underwent remifentanil induction and maintenance,
and investigate corresponding influence on the levels of blood cortisol and β-endorphin.