Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation

• Status: Not yet recruiting
• Trial end date: 2025-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Septic shock patients with invasive mechanical ventilation who were randomly enrolled in ICU were divided into esketamine group (test group) and remifentanil group (control group) according to the ratio of 1:1. The dose of vasopressor, the time of mechanical ventilation, the incidence of intestinal dysfunction and the dose of propofol were compared between the two groups. Through statistical analysis, it was determined whether esketamine combined with propofol could improve the prognosis of septic shock patients with invasive mechanical ventilation and reduce the adverse reactions of analgesic and sedative drugs compared with remifentanil combined with propofol.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The First Hospital of Jilin University
• Treatments: Esketamine; Propofol; Remifentanil

Criteria

Inclusion Criteria:

1. Adults (aged 18-75 years)

2. Septic shock patients with invasive mechanical ventilation

3. Use norepinephrine (the only vasoactive drug) to maintain the target map ≥ 65 mmHg

4. BMI 18.5-23.9kg/m2

Exclusion Criteria:

1. Pregnant or lactating women;

2. Patients allergic to planned drugs;

3. Hypertension patients with poor control;

4. Patients with mental illness, chronic pain, seizures, elevated intracranial pressure, severe ischemic heart disease, and bronchial asthma;

5. Patients included in other trial items;

6. Other reasons that the researcher considers unsuitable to participate in this study.