Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery

• Status: Unknown status
• Trial end date: 2006-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis of this study is that the antifibrinolytic drugs aprotinin and tranexamic acid equally influence bleeding tendency and transfusion requirement in patients undergoing first time cardiac procedures with a low risk of increased postoperative bleeding.Only patients undergoing first time CABG or first time aortic valve replacement are included in this study.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: German Heart Center
• Treatments: Aprotinin; Tranexamic Acid

Criteria

Inclusion Criteria:

• informed consent

• Patients undergoing primary CABG or Aortic valve replacement surgery

Exclusion Criteria:

• Previous sternotomy

• OPCAB surgery

• urgent/emergency operation

• Coumadin treatment

• previous aprotinin exposure

• preoperative renal impairment (Creatinine > 2 mg/dL)

• patients refusing blood transfusions

• no informed consent