Comparison of Aripiprazole Versus Risperidone on Brain Morphology Using MRI
Status:
Unknown status
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Significant changes in brain morphology are observed in people with first-episode psychosis.
Studies have shown that total brain volume and particular brain structures are decreased in
people with psychosis disorders. Recent evidence suggests that some atypical antipsychotic
drugs can maintain or increase brain volumes. Thus, we plan to use MRI scans to measure
changes in brain morphology in subjects recently diagnosed with bipolar or psychosis
disorders who are taking the atypical antipsychotic drugs aripiprazole or risperidone.
Secondary objectives include taking blood samples for fasting metabolic indices and
neuropsychiatric measures for comparisons between drug treatments.