Overview

Comparison of Autologous Serum Versus Preservative Free Artificial Tear

Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
0
Participant gender:
All
Summary
Dry eye is a significant adverse effect of isotretinoin causing patients to use ophthalmic medications. For this reason, many patients using isotretinoin are referred to ophthalmology clinic because of discomfort symptoms. In the literature, there are studies suggesting superiority of Autologous serum drops regarding effects on ocular surface when compared to artificial tear. In addition, Autologous serum was also used in several corneal pathologies with successful outcomes. No data regarding use in the ocular adverse effects of isotretinoin was found in the literature; however, investigators think that it may be an effective alternative in the treatment of dry eye developed during isotretinoin use due to positive effects on ocular surface, epithelial regeneration and anti-inflammatory effect. Autologous serum can be a choice of ophthalmologists in routine practice by increasing number of comprehensive studies investigating effectiveness, safety and long-terms effects of Autologous serum therapy.In this study, it was aimed to investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous serum and Preservative free artificial tear in the patients with dry eye disease.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Niğde State Hospital
Treatments:
Dextrans
Isotretinoin
Lubricant Eye Drops
Ophthalmic Solutions
Povidone
Criteria
Inclusion Criteria

• isotretinoin use for any reason

Exclusion Criteria:

- corneal pathologies such as dry eye illness before isotretinoin treatment

- previous cornea surgery, injury or keratitis

- active ocular infection

- meibomian gland dysfunction

- excessive allergic reaction that may be associated with dry eye

- glaucoma therapy use

- severe anemia

- previously use of PFAT or AS for any reason

- (Hb<10 g/dL) and elevated hepatic function tests requiring withdrawal of therapy