Comparison of Changes in Serum 25(OH)D Concentrations Following Vitamin D Supplementation With Chewable Tablets Versus Pills

• Status: Completed
• Trial end date: 2018-05-09
• Target enrollment: 0
• Participant gender: All

Summary

This is a 6-month cross-over trial of vitamin D supplementation in 38 healthy men and women aged 18 years and older. The primary aim is to compare the change in serum 25(OH)D concentration following vitamin D supplementation with chewable tablets versus pills. Secondary aims are to evaluate satisfaction and adherence to the vitamin D chewable tablet supplement. Questionnaires on physical activity, sunlight exposure and dairy product consumption will be administered to adjust for confounding factors. A questionnaire will be administered to assess satisfaction and pill count to evaluate adherence to treatment. This research intends to test the hypothesis that the vitamin D chewable tablet supplement is as effective as a traditional vitamin D pill supplement to increase serum 25(OH)D concentrations.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre Hospitalier Universitaire de Québec, CHU de Québec; CHU de Quebec-Universite Laval
• Collaborators: Anne-Sophie Morisset; Khlôros Technology
• Treatments: Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Caucasian men and women;

• Aged 18 years and older;

• Having a serum 25(OH)D concentration of 75 nmol/L or less.

Exclusion Criteria:

• Regular consumption of a supplement containing > 400 IU/d of vitamin D over the last 2 months;

• Intestinal malabsorption;

• Cirrhosis;

• Renal insufficiency (creatinine clearance <60 ml/min);

• Hypercalcemia;

• Pregnancy;

• Breastfeeding;

• Inability to provide informed consent.