Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma
Status:
Completed
Trial end date:
2021-11-30
Target enrollment:
Participant gender:
Summary
Melasma is an acquired skin disorder characterized by hyper-melanosis. Melasma is a term that
originates from the Greek root "melas" (black color) and was formerly known as chloasma.
Melasma is more common in sun-exposed tissues such as the cheeks, chin, upper lip, and
forehead. Melasma is a common dermatological disorder with a frequency of 8.8 percent in the
United States, but it can be as high as 40 percent amongst females. Melasma affects mostly
ladies and is most common throughout their reproductive years .
Melasma causes an increase in melanin pigment synthesis owing to a surge in the number of
melanosomes, which are membrane-bound cell organelles inside melanocytes where melanin
biosynthesis occurs and is transported to keratinocytes. Except in rare situations, the
number of melanocytes will not be enhanced. Melanocytes will grow in size, and dendrites will
become more visible. Despite the fact that the specific causation is unknown, some elements
are thought to have a role in the pathophysiological mechanisms of melasma). Among these, sun
exposure (UV light) is the most powerful primary trigger for its growth, which explains
melisma's propensity for certain areas of the body. Other major determinants include genetic
predisposition, and female hormones - both endogenous (that is, during pregnancy) and
exogenous (that is, during pregnancy) (contraceptives and hormone replacement therapy).
Thyroid problems, medications, and cosmetics can all be aggravating factors. Evaluation and
prevention of triggering variables are essential in order to avoid recurrence .
The peeling effect of glycolic acid is due to chemo exfoliation capabilities, that rely upon
aiding the elimination of keratinocytes, resulting in melanin reduction and speeding up the
regeneration of skin. TA suppresses UV-stimulated plasmin action in keratin cells by blocking
plasminogen appending to the keratin cells, resulting from lower free arachidonic acid levels
or to reduced capacity of prostaglandins production, which reduces melanocyte tyrosinase
activity .
The study's implications are to analyze the efficacy of these two drugs in order to assess
the better outcome of patients with evidence-based management.