Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery

• Status: Completed
• Trial end date: 2019-03-27
• Target enrollment: 0
• Participant gender: Female

Summary

Regional anesthesia is commonly used for elective and emergency cesarean delivery. It provides numerous safety advantages when compared to general anesthesia for both the mother and fetus1. Epidurals also have the added benefit of being able to provide pain relief throughout labor and in the event of cesarean delivery, epidural analgesia can be "extended" to provide surgical anesthesia. Numerous studies have been performed to assess the onset times of various local anesthetics when administered through an epidural catheter. Attempts to reduce anesthetic onset time and improve the quality of intraoperative analgesia have been attempted by using different local anesthetic solutions and by the addition of other drugs to the epidural solution (such as epinephrine, fentanyl and sodium bicarbonate).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Arkansas
• Treatments: Chloroprocaine; Epinephrine; Epinephryl borate; Fentanyl; Lidocaine; Procaine; Racepinephrine

Criteria

Inclusion Criteria:

• ≥ 18 years of age for the mother

• Singleton pregnancy

• Gestation > 36 weeks

• American Society of Anesthesiologist (ASA) class II

• Provides written consent

• Infant of mother

Exclusion Criteria:

• Patient refusal

• Non-elective or urgent/emergent cesarean sections

• ASA class III or above

• Unable to understand English

• Significant back surgery or scoliosis

• Known fetal abnormality

• Weight > 120 kg

• Height < 150 cm

• Allergy to local anesthetics

• Concurrent use of sulfonamides